Yes, absolutely. All Major retailers accept promo codes and accept in store and online promo codes. Manufactures also have their promocodes that stores do accept. Stores may not be able to combine multiple discounts for every single time but as long as you can stack more than one kind of discount on any item, it is considered Extreme Couponing. You may not be able to bring down the total cart value from $500 to $15 like the TV show but you will definitely save a lot of your hard earned money.